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Synthesis of unnatural amino acids and other blocks

[Pro34]Peptide YY, PYY, human

Name
[Pro34]Peptide YY, PYY, human
Molecular structural formula
Purity
≥95%
CAS Number
179986-95-9
Formula
C194H294N54O56
MW
4278.83
Target
Neuropeptide Y Receptor
Sequence
Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Pro-Arg-Tyr- NH2
Sequence Shortening
YPIKPEAPGEDASPEELNRYYASLRHYLNLLTRPRY-NH2
References
[1]. Dumont Y, et al. Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type. Brain Res Mol Brain Res. 1994 Oct;26(1-2):320-4. [2]. Morales-Medina JC, et al. Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Neuropharmacology. 2012 Jan;62(1):200-8.
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Product details
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(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM.